This Four-volume Set Lncs 13701-13704 Constitutes Contributions Of The Associated Events Held At The 11th International Symposium On Leveraging Applications Of Formal Methods, Isola 2022, Which Took Place In Rhodes, Greece, In Octobernovember 2022.the Contributions In The Four-volume Set Are Organized According To The Following Topical Sections: Specify This - Bridging Gaps Between Program Specification Paradigms; X-by-construction Meets Runtime Verification; Verification And Validation Of Concurrent And Distributed Heterogeneous Systems; Programming - What Is Next: The Role Of Documentation; Automated Software Re-engineering; Dime Day; Rigorous Engineering Of Collective Adaptive Systems; Formal Methods Meet Machine Learning; Digital Twin Engineering; Digital Thread In Smart Manufacturing; Formal Methods For Distributed Computing In Future Railway Systems; Industrial Day.