This Book Constitutes The Refereed Proceedings Of The 34th International Conference On High Performance Computing, Isc High Performance 2019, Held In Frankfurtmain, Germany, In June 2019.the 17 Revised Full Papers Presented Were Carefully Reviewed And Selected From 70 Submissions. The Papers Cover A Broad Range Of Topics Such As Next-generation High Performance Components; Exascale Systems; Extreme-scale Applications; Hpc And Advanced Environmental Engineering Projects; Parallel Ray Tracing - Visualization At Its Best; Blockchain Technology And Cryptocurrency; Parallel Processing In Life Science; Quantum Computerscomputing; What's New With Cloud Computing For Hpc; Parallel Programming Models For Extreme-scale Computing; Workflow Management; Machine Learning And Big Data Analytics; And Deep Learning And Hpc.