Organs-on-chips

Recent Advances In Microsystems Technology And Cell Culture Techniques Have Led To The Development Of Organ-on-chip Microdevices That Produce Tissue-level Functionality, Not Possible With Conventional Culture Models, By Recapitulating Natural Tissue Architecture And Microenvironmental Cues Within Microfluidic Devices. Since The Physiological Microenvironments In Living Systems Are Mostly Microfluidic In Nature, The Use Of Microfluidic Devices Facilitates Engineering Cellular Microenvironments; The Microfluidic Devices Allow For Control Of Local Chemical Gradients And Dynamic Mechanical Forces, Which Play Important Roles In Cellular Viability And Function. The Organ-on-chip Microdevices Have Great Potential To Promote Drug Discovery And Development, To Model Human Physiology And Disease, And To Replace Animal Models For Efficacy And Toxicity Testing.