This book constitutes the refereed proceedings of the 35th International Conference on High Performance Computing ISC High Performance 2020 held in FrankfurtMain Germany in June 2020.The 27 revised full papers presented were carefully reviewed and selected from 87 submissions. The papers cover a broad range of topics such as architectures networks ampamp infrastructure artificial intelligence and machine learning data storage ampamp visualization emerging technologies HPC algorithms HPC applications performance modeling ampamp measurement programming models ampamp systems software. The conference was held virtually due to the COVID19 pandemic.ChaptersampampnbspScalable Hierarchical Aggregation and Reduction Protocol SHARP StreamingAggregation Hardware Design and Evaluation Solving Acoustic Boundary Integral Equations Using High Performance Tile LowRank LU Factorization Scaling Genomics Data Processing with MemoryDriven Computing to Accelerate Computational Biology FootprintAware Power Capping for Hybrid Memory Based Systems and PatternAware Staging for Hybrid Memory Systems areampampnbspavailable open access under a Creative Commons Attribution 4.0 International License via link.